Primary Splenic Diffuse Large B-Cell Lymphoma with Massive Splenomegaly
Issue: 2023 - Volume 6 [Issue 2]
S. N. Jatal *
Jatal Hospital and Research Centre, Latur, India.
Jatal Hospital and Research Centre, Latur, Tata Hospital, Mumbai, India.
Department of Pathology, MIMSR Medical College, Latur, India.
*Author to whom correspondence should be addressed.
Primary malignancies of the spleen are very rare, diffuse large B-cell lymphoma of the spleen is a rare primary neoplasm. Primary splenic diffuse large B-cell lymphoma is a type of non-Hodgkin’s lymphoma that constitute, less than 1% of non -Hodgkin’s lymphoma and less than 2% of all lymphomas. Primary splenic lymphoma has been associated with the hepatitis C and HIV virus. It affects men more than women and present in late middle age.
Patient with diffuse large B cell lymphoma typically present with fever, fatigue, weight loss, palpable splenomegaly and left upper quadrant pain. Diffuse large B cell lymphoma stage I being limited to the spleen, whereas stage II spleen and hilar Lymph-node involvement and stage III is distant metastasis including liver and surrounding organs involvements, stomach, pancreas, kidney and colon. Stage I disease, a splenectomy is the standard treatment for DLBSL. Radiation and chemotherapy can be used. When the cancer is confined to the spleen, the prognosis is quite favourable with a median survival of 7.48 years.
We are reporting an extremely rare case of primary splenic lymphoma in a 45 years old female patient, presented with abdominal pain and huge splenomegaly. The CT revealed a bulky, low density, irregular mass in the spleen and clinically disease limited to spleen only. So we performed open total splenectomy.
Keywords: Diffuse large B. cell lymphoma, primary splenic lymphoma, splenomegaly
How to Cite
Jillian L. Van Vliet. Primary diffuse large B cell lymphoma of the spleen. Journal of Diagnostic Medical Sonography. 2010; 26(3):147–149. © The Author(s) Reprints and permission: Available:http://www. sagepub.com/journalsPermissions.nav DOI: 10.1177/8756479310368431
Khalid S, Daw JH, Daw H, Haddad A. Primary splenic diffuse large B-cell lymphoma: A rare case of massive splenomegaly and thrombocytopenia. Cureus. 2018;10(7):e3026.
DOI: 10.7759/cureus.3026. PMID: 30254815; PMCID: PMC6150744.
Ismail S, Ali F, Ajamieh H, Kanaan S, Issa R, Daoud A, Alshehabi Z. Primary splenic anaplastic variant of diffuse large B-cell lymphoma: A case report. J Med Case Rep. 2021;15(1):227.
DOI: 10.1186/s13256-021-02846-x. PMID: 33952307; PMCID: PMC8101127.
Bairey O, Shvidel L, Perry C, Dann EJ, Ruchlemer R, Tadmor T, Goldschmidt N. Characteristics of primary splenic diffuse large B-cell lymphoma and role of splenectomy in improving survival. Cancer. 2015;121:2909-2916.
Taha A, Baiomy, Ola A, Harb, Ahmed A. Obaya, Loay M. Gertallah, Primary splenic non-Hodgkin lymphoma of diffuse large B cell type; A case report and review of the literature,Human Pathology: Case Reports.
Rajendran T, Kini JR, Abna A, et al Clinical benefit of R-CHOP without splenectomy in stage I primary splenic diffuse large B-cell lymphoma BMJ Case Reports CP. 2022; 15:e246610.
Hui Li and others, Unusual Presentation of Primary Splenic Diffuse Large B Cell Lymphoma of Red Pulp, American Journal of Clinical Pathology. 2015;144(suppl_2). Available:https://doi.org/10.1093/ajcp/144.suppl2.117
Chen, Yue-Ren, Hwa-Koon Wu, and Yang-Yuan Chen. Unusual rapid growth of primary splenic diffuse large B-cell lymphoma with extensive necrosis. Diagnostics. 2023;13(1):35. Available:https://doi.org/10.3390/diagnostics13010035
Maia Neves N, Lopes AP, Carvalho Coelho S, Raimundo A, Mafra MM, Bayão Horta A. Primary splenic diffuse large B-cell lymphoma: A case report. EJCRIM. 2023;10 DOI:10.12890/2023_003932
Maia Neves N, Lopes AP, Carvalho Coelho S, Raimundo A, Mafra MM, Bayão Horta A. Primary splenic diffuse large B-cell lymphoma: A case report. EJCRIM. 2023;10. DOI:10.12890/2023_003932