Comparison of Preoperative Subconjunctival Injection of Mitomycin C versus Conjunctival Auto Graft with Fibrin Glue in the Management of Primary Pterygium - A Clinical Study

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Mridula V. Amarnath


Aim: To evaluate the outcome of preoperative subconjunctival Mitomycin C to conjunctival auto grafting using fibrin glue with respect to the recurrence rate and complications.

Methodology:  A prospective randomized hospital based study was conducted. 60 eyes were taken into consideration with primary progressive pterygium and were randomly divided into 2 groups of 30 each. In group A subconjunctival injection of Mitomycin C (MMC) 0.1 ml of 0.1 mg/ml was given 1 month before bare sclera technique and in group B pterygium excision with conjunctival auto graft using fibrin glue was performed. They were regularly followed up for 18 months.

Results: The mean age of the patients in this study was a 39.6±12.3 year with females outnumbering the males. The mean follow up period of group A was 10.6 ±5.44 months while in group B it was 11.2 ±4.49 months. It was found out that the recurrence rate with subconjunctival MMC before bare sclera technique was 3.4 %while the recurrence rate with conjunctival autograft using fibrin glue was6.7%. The average surgery time was more in group B than compared to Group A. Both the techniques were not associated with any vision threatening complications.

Conclusion: Administration of subconjunctival injection of MMC 1 month before the bare sclera technique is considered to be safer, economical, less time consuming, technically less demanding and as effective as conjunctival autograft with fibrin glue.

Pterygium, bare sclera, MMC, auto graft.

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How to Cite
Amarnath, M. V. (2020). Comparison of Preoperative Subconjunctival Injection of Mitomycin C versus Conjunctival Auto Graft with Fibrin Glue in the Management of Primary Pterygium - A Clinical Study. Asian Journal of Research in Surgery, 4(2), 30-34. Retrieved from
Original Research Article


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