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Arteriopathies due to drug-administration have been described. However, the data is insufficient. Ergotism is caused by ergotamine derivatives intake. It can lead to arterial spasms, causing limb claudication and even distal necrosis in some cases. We report a 42-year-old female patient with a 2-year history of ergot derivatives treatment for migraine attacks. She presented with acute ischemia of the left hallux. She did not take any concomitant medications. Blood test was normal, as well as the arterial Doppler ultrasound of the lower limb. No other cause that could explain this ischemia was present. Discontinuation of ergotamine and vasodilator treatment resolved the ischemia, without sequelae. Physicians should be aware that ergotamine may cause ischemia. Stopping ergotamine is important.
Dardaine V, Lasfargues G, Guilmot JL. Angiopathies d’origine iatrogène. Tensiologie. 1989;88:10-3
Zajdel P, Bednarski M, Sapa J, Novak G. Ergotamine and nicergoline facts and myths. Pharmacological Reports. 2015(67) 360–36.
Paraskevopoulos JA, Teasdale DE, Cuschieri RJ. Severe reversible arterial spasm with ergotamine. Br J Clin Pract. 1995;49:214.
Adam G, Kurt T, Çınar C, Sarıyıldırım A. Ergotamine-induced vasospastic ischemia mimicking arterial embolism: Unusual case. Ulus Travma Acil Cerrahi Derg. 2014;20 (4):291-4.
Fukui S, Coggia M, Goëau-Brissonnière O. Acute upper extremity ischemia during concomitant use of ergotamine tartrate and ampicillin. Ann Vasc Surg. 1997;11: 420-4.
McKiernan TL, Bock K, Leya F, Grassman E, Lewis B, Johnson SA. Ergot induced peripheral vascular insufficiency, non-interventional treatment. Cathet Cardiovasc Diagn. 1994;31:211-4.